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Cefixime Study Group Infection

Verghese A, Roberson B, Kalbfleisch JH et al. Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbation of chronic bronchitis. Antimicrob Agents Chemother. AIDS. This medicine is not a cure for HIV or AIDS. Antibacterial; β-lactam antibiotic; third generation cephalosporin. zyprexa to buy no script

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Truvada emtricitabine and tenofovir. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Fire ants. Soak the affected area in ice water and use an anti-itch medicine to calm your skin. Megran DW, Lefebvre K, Willetts V et al. Single-dose oral cefixime versus amoxicillin plus probenecid for the treatment of uncomplicated gonorrhea in men. Antimicrob Agents Chemother.

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For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same times every day. Saito A, Yamaguchi K, Shigeno Y et al. Clinical and bacteriological evaluation of Branhamella catarrhalis in respiratory infections. Drugs. Milatovic D. Evaluation of cefadroxil, penicillin and erythromycin in the treatment of streptococcal tonsillopharyngitis.

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The following in vitro data are available, but their clinical significance is unknown. AHFS Drug Information 2003. McEvoy GK, ed. Cephalosporins General Statement. Most of these abnormalities were transient and not clinically significant.



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Elderly subjects do not require dosage adjustments unless they have diminished renal function. Add soothing sounds to silence. Tinnitus may bother you more when it's quiet. Please refer to the for information on shortages of one or more of these preparations. Cefprozil oral suspension Cefzil contains phenylalanine. Check with your doctor before taking this medicine. Cefpodoxime proxetil is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions listed below. Gremse DA, Dean PC, Farquhar DS et al. Cefixime and antibiotic-associated colitis. Suprax, and may range in severity from mild diarrhea to fatal colitis. Your doctor may need to remove extra fluid from the joint before injecting the medicine. Dosage is based on your medical condition and response to treatment. If a child is using this medicine, tell your doctor if the child has any changes in weight. Lamivudine doses are based on weight in children, and any changes may affect your child's dose. Counsel patients that antibacterial drugs, including cefixime, should only be used to treat bacterial infections. Resistance to cefixime in isolates of Haemophilus influenzae and Neisseria gonorrhoeae is most often associated with alterations in penicillin-binding proteins PBPs. Cefixime may have limited activity against Enterobacteriaceae producing extended spectrum beta-lactamases ESBLs. Pseudomonas species, Enterococcus species, strains of Group D streptococci, Listeria monocytogenes, most strains of staphylococci including methicillin-resistant strains most strains of Enterobacter species, most strains of Bacteroides fragilis, and most strains of Clostridium species are resistant to cefixime. Do not use capsules or conventional tablets for treatment of AOM. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. It is important to have this medication injected on schedule. It may take up to 3 injections before the full benefits of this medication occur. For Susceptibility Testing of Streptococcus pneumoniae. Epivir should not be given to a child younger than 2 years old.



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Time to peak concentration was not significantly different between fed and fasted subjects. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Gales MA. Recognition of severe cefixime-induced diarrhea. Clin Pharm. Use and dose must be determined by your doctor. As with other antibiotics, prolonged use of cefpodoxime proxetil may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient's condition is essential. If superinfection occurs during therapy, appropriate measures should be taken. These differences were small and do not indicate a need for dosage adjustment of the drug in the elderly. Before prescribing SUPRAX chewable tablets in a patient with PKU, consider the combined daily amount of phenylalanine from all sources, including SUPRAX chewable tablets. ponstel



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When available, the clinical microbiology laboratory should provide cumulative reports of in vitro susceptibility test results for antimicrobial drugs used in local hospitals and practice areas as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. These reports should aid the physician in selecting an antibacterial drug for treatment. Children who weigh more than 30 pounds 14 kilograms should use the tablet form of lamivudine if possible. Lamivudine liquid may not be as effective. Individual adverse reactions included diarrhea 16%, loose or frequent stools 6%, abdominal pain 3%, nausea 7%, dyspepsia 3%, and flatulence 4%. The incidence of gastrointestinal adverse reactions, including diarrhea and loose stools, in pediatric patients receiving the suspension was comparable to the incidence seen in adult patients receiving tablets. In patients with transient or persistent reduction in urinary output due to renal insufficiency, the total daily dose of cefpodoxime proxetil should be reduced because high and prolonged serum antibiotic concentrations can occur in such individuals following usual doses. Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics. Tell your doctor if your condition persists or worsens. The cefixime suspension liquid contains sucrose. Talk to your doctor before using this form of cefixime if you have diabetes. Suspend in a total of 43 mL of distilled water. Method: First, shake the bottle to loosen granules. Then add the water in two approximately equal portions, shaking vigorously after each aliquot of water. macing.info coversyl



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Kiani R, Johnson D. Comparative multicenter studies of cefixime and amoxicillin in the treatment of respiratory tract infections. Am J Med. Wald ER, Applegate KE, Bordley C et al. Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years. Pediatrics. Harrison CJ, Chartrand SA, Rodriguez W et al. Middle ear effuxion concentrations of cefixime during acute otitis media with effusion and otitis media with effusion. Go to bed and get up at the same time every day. If you have a “strep” infection, you should keep taking this medicine for at least 10 days. This is especially important in “strep” infections since serious heart or kidney problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return. The number of capsules or tablets or teaspoonfuls of suspension that you take depends on the strength of the medicine. Of the 3338 patients in multiple-dose clinical studies of cefpodoxime proxetil film-coated tablets, 521 16% were 65 and over, while 214 6% were 75 and over. No overall differences in effectiveness or safety were observed between the elderly and younger patients. Machka K, Balg H, Braveny I. In vitro activity of new antibiotics against Haemophilus influenzae. Eur J Clin Microbiol Infect Dis. Possible increased oral bioavailability; 1 35 37 not considered clinically important. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Treatment of uncomplicated UTIs 1 2 5 40 51 64 74 75 182 caused by susceptible E. coli 1 2 40 51 64 74 75 182 or Proteus mirabilis; 1 2 40 51 74 75 182 also has been used for treatment of uncomplicated UTIs caused by susceptible Citrobacter spp. Krepel CJ, Schopf LR, Gordon RC et al. Comparative in vitro activity of cefixime with eight other antimicrobials against Enterobacteriaceae, streptococci, and Haemophilus influenzae. Curr Ther Res. Size “00EL” capsules with pink opaque cap and pink opaque body, imprinted with “LU” on cap and “U43” on body in black ink, containing white to yellowish white granular powder containing 400 mg of cefixime as the trihydrate. pharmacy gemfibrozil kada



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Suite 1400, Wayne, PA 19087-1898, 1998. Anon. Choice of cephalosporins. Med Lett Drugs Ther. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Safety and effectiveness of cefixime in children aged less than six months old have not been established. The incidence of gastrointestinal adverse reactions, including diarrhea and loose stools, in the pediatric patients receiving the suspension, was comparable to the incidence seen in adult patients receiving tablets. Pink, round tablet, debossed with “SUPRAX 100” on one side and “LUPIN” on other side. Get emergency medical help if you have signs of an allergic reaction to Suprep: hives; difficult breathing; swelling of your face, lips, tongue, or throat.



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F. Shake well before using. Keep container tightly closed. The mixture may be used for 14 days. Discard unused portion after 14 days. Importance of discontinuing cefixime and informing clinician if an allergic reaction occurs. For methods usually done in silence, such as meditation, a quiet background noise may help mask tinnitus symptoms and improve your concentration. Each 5 mL of Vantin Oral Suspension contains cefpodoxime proxetil equivalent to 50 mg or 100 mg of cefpodoxime activity after constitution and the following inactive ingredients: artificial flavorings, butylated hydroxy anisole BHA carboxymethylcellulose sodium, microcrystalline cellulose, carrageenan, citric acid, colloidal silicon dioxide, croscarmellose sodium, hydroxypropylcellulose, lactose, maltodextrin, natural flavorings, propylene glycol alginate, sodium citrate, sodium benzoate, starch, sucrose, and vegetable oil. Counts GW, Baugher LK, Ulness BK et al. Comparative in vitro activity of the new oral cephalosporin cefixime. Eur J Clin Microbiol Infect Dis. Crosses the placenta. 2 23 Not detected in human milk following a single 100-mg oral dose. Susceptible" indicates that the pathogen is likely to be inhibited if the concentration of the antimicrobial compound in the blood reaches usually achievable levels. A report of "Intermediate" indicates that the results should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone which prevents small technical factors from causing major discrepancies in interpretation. A report of "Resistant" indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected. The interpretive value for Streptococcus spp. Skin: Skin moniliasis, urticaria, fungal dermatitis, acne, exfoliative dermatitis, maculopapular rash. Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. SUPRAX is indicated in the treatment of adults and pediatric patients six months of age or older with otitis media caused by susceptible isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes. Efficacy for Streptococcus pyogenes in this organ system was studied in fewer than 10 infections. Protect your hearing. Loud noise is a common cause of tinnitus. It can also make your symptoms worse for a short time. Cephalosporins are used to treat infections in many different parts of the body. They are sometimes given with other antibiotics. Some cephalosporins given by injection are also used to prevent infections before, during, and after surgery. However, cephalosporins will not work for colds, flu, or other virus infections. SUPRAX cefixime is contraindicated in patients with known allergy to cefixime or other cephalosporins. Tell your doctor right away if you have see Side Effects section. Faulkner RD, Bohaychuk W, Haynes JD et al. The pharmacokinetics of cefixime in the fasted and fed state. Eur J Clin Pharmacol. 1988; 34: 5225-8. If you miss a dose of this medicine, take it as soon as possible. This will help to keep a constant amount of medicine in the blood or urine. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. much does letrozole



Suprax warnings

Capsules containing 400 mg of cefixime are bioequivalent to conventional tablets containing 400 mg of the drug when administered under fasting conditions. Adequate data on CSF levels of cefpodoxime are not available. Capsules and conventional tablets: Administer without regard to meals. 1 See Food under Pharmacokinetics. McLinn SE. Randomized, open label, multicenter trial of cefixime compared with amoxicillin for treatment of acute otitis media with effusion. Pediatr Infect Dis. Cefixime Study Group. Infection. Scott HV, Pannowitz D. Cefixime: clinical trial against otitis media and tonsillitis. prinivil



Renal: Increases in BUN and creatinine

Next, your doctor may use a needle to draw out any extra fluid that's in your knee. Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Vantin, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. Drinking alcoholic beverages or taking other alcohol-containing preparations for example, elixirs, cough syrups, tonics, or injections of alcohol while receiving these medicines may cause problems. The problems may occur if you consume alcohol even several days after you stop taking the cephalosporin. Drinking alcoholic beverages may result in increased side effects such as abdominal or stomach cramps, nausea, vomiting, headache, fainting, fast or irregular heartbeat, difficult breathing, sweating, or redness of the face or skin. These effects usually start within 15 to 30 minutes after you drink alcohol and may not go away for up to several hours. The presence of other medical problems may affect the use of cephalosporins. Avoid drinking alcohol. Dangerous side effects could occur. This may interfere with certain hematologic studies or transfusion cross-matching procedures. Children weighing more than 45 kg or older than 12 years should be treated with the recommended adult dose. SUPRAX cefixime chewable tablets must be chewed or crushed before swallowing. Join a support group. Talking with other people with the same condition can help you feel less alone. You'll also learn different approaches for coping with tinnitus. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. If your reaction is severe, he may also prescribe antivenom. After reconstitution: Store at room temperature or under refrigeration. Keep tightly closed. duloxetine



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Consider CDAD if diarrhea develops during or after therapy and manage accordingly. 1 42 177 178 Obtain careful medical history since CDAD may occur as late as 2 months or longer after anti-infective therapy is discontinued. Daikos GL, Kathpalia SB, Sharifi R et al. Comparison of ciprofloxacin and beta-lactam antibiotics in the treatment of urinary tract infections and alteration of fecal flora. Am J Med. Yellow No. 6, hydroxypropylcellulose, hypromellose, lactose hydrous, magnesium stearate, propylene glycol, sodium lauryl sulfate and titanium dioxide. Faulkner RD, Sia LL, Look ZM et al. Bioequivalency of solid oral dosage forms of cefixime. Int J Pharm. As with standardized dilution techniques, diffusion methods require the use of laboratory control microorganisms that are used to control the technical aspects of the laboratory procedures. Has been used for treatment of disseminated Lyme disease. 181 Other cephalosporins cefotaxime, ceftriaxone, cefuroxime axetil usually recommended by IDSA and others when a cephalosporin is used in the treatment of Lyme disease. SUPRAX is indicated in the treatment of adults and pediatric patients six months of age or older with uncomplicated urinary tract infections caused by susceptible isolates of Escherichia coli and Proteus mirabilis. Of patients with diarrhea, 10% had C. difficile organism or toxin in the stool. Cefpodoxime has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections, as described in the section. If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Oksi J, Nikoskelainen J. Comparison of oral cefixime and intravenous ceftriaxone followed by oral amoxicillin in disseminated lyme borreliosis. Eur J Clin Microbiol Infect Dis.



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Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Kishiyam JL. The cross-reactivity and immunology of β-lactam antibiotics. Drug Saf. NOTE: The efficacy of cefpodoxime in treating male patients with rectal infections caused by N. gonorrhoeae has not been established. Data do not support the use of cefpodoxime proxetil in the treatment of pharyngeal infections due to N. gonorrhoeae in men or women. If tinnitus keeps you from sleeping well, this can become a vicious cycle. Quantitative methods that require measurement of zone diameters can also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. The zone size should be determined using a standardized test method. These quality control ranges are applicable to tests performed by a broth microdilution procedure using Haemophilus Test Medium HTM. These quality control ranges are applicable to tests performed by agar dilution only using GC agar base with 1% defined growth supplement. These quality control ranges are applicable to tests performed by the broth microdilution method only using cation-adjusted Mueller-Hinton broth with 2 to 5% lysed horse blood. Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure requires the use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 10 mcg cefpodoxime to test the susceptibility of microorganisms to cefpodoxime. Wormser GP, Dattwyler RJ, Shapiro ED et al. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. There may be other drugs that can interact with cefixime. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start taking a new medication without telling your doctor. Learn what makes tinnitus worse for you. Some people report that certain foods, drinks, or drugs can make their symptoms worse. Not everyone is affected the same way, so try to avoid triggers one at a time and keep a written log. Note: A suggested dose has been determined for each pediatric weight range. sominex to purchase in canada



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Cefixime recommended by CDC as an alternative in patients with urogenital or rectal gonorrhea when ceftriaxone cannot be used or not available; 197 used in conjunction with single dose of oral azithromycin or 7-day regimen of oral doxycycline. Included as part of the PRECAUTIONS section. To reconstitute, suspend with 26 mL water. Method: Tap the bottle several times to loosen powder contents prior to reconstitution. Add approximately half the total amount of water for reconstitution and shake well. Add the remainder of water and shake well. This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using cefixime. Centers for Disease Control and Prevention CDC. Update to CDC's Sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections. MMWR Morb Mortal Wkly Rep. Rossi R, Castellani P, Younes G et al. Activity of FCE 22891 compared with cefuroxime axetil and cefixime in pulmonary and subcutaneous infections in mice. J Antimicrob Chemother. Lederle, Pearl River, NY: Personal communication. Transient elevations in BUN or creatinine, acute renal failure. pharmacy express prandin



Suprax ingredients

Powell M. In vitro susceptibility of Haemophilus influenzae to cefixime. Antimicrob Agents Chemother. Susceptible S indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the site of infection. A report of Intermediate I indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of the drug can be used. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of Resistant R indicates that the antimicrobial drug is not likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the infection site; other therapy should be selected. Discard unused portion after 14 days. Patients with cystic fibrosis may receive 30 to 50 mg per kilogram kg 13. Distributed into milk in rats; 36 not known whether distributed into milk in humans. 1 Discontinue nursing or the drug. NSAID nonsteroidal anti-inflammatory drug. This drug passes into milk. The dose of these medicines will be different for different patients. Treatment of acute exacerbations of chronic bronchitis caused by S. pneumoniae, 1 2 23 44 70 72 103 H. influenzae, 1 2 23 44 70 72 103 or M. catarrhalis. digoxin



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How should I take cefixime Suprax?


Set aside 7 to 9 hours for at night

Taking this medicine will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Take Suprep Bowel Prep Kit exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may need to use 2 bottles to get your entire dose. It is not known whether magnesium, potassium, and sodium sulfates passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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What happens if I overdose Suprax? Jorgensen JH, Doern GV, Thornsberry C et al. Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrob agents. Diagn Microbiol Infect Dis. Epivir can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have: severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate, itching, loss of appetite, dark urine, clay-colored stools, or jaundice yellowing of the skin or eyes. Respiratory - asthma, cough, epistaxis, rhinitis, wheezing, bronchitis, dyspnea, pleural effusion, pneumonia, sinusitis.

Use of suprax

Peterson WL. Helicobacter pylori and peptic ulcer disease. N Engl J Med. You may not need to avoid every possible trigger. Instead, notice which things affect your symptoms. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Epivir only for the indication prescribed.

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NOTE: Cefpodoxime is inactive against most strains of Pseudomonas and Enterobacter. Do not use anti-diarrhea products or pain if you have any of these symptoms because these products may make them worse. Hypersensitivity reactions such as anaphylaxis including shock and fatalities angioedema, serum sickness-like reactions, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported. Possible emergence and overgrowth of nonsusceptible bacteria or fungi, especially Enterobacter, Pseudomonas, enterococci, staphylococci, or Candida. 1 5 Careful observation of the patient is essential. 1 Institute appropriate therapy if superinfection occurs.

If an or sting causes a severe reaction, get medical help right away. Girgis NI, Kilpatrick ME, Farid Z et al. Cefixime in the treatment of enteric fever in children. Drugs Exp Clin Res. Primarily, these discontinuations were for gastrointestinal disturbances, usually diarrhea, vomiting, or rashes. Keep track of the amount of medicine used from each new bottle. Oxazepam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. What happens if I miss a dose?

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